[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” width=”100%” max_width=”1789px” min_height=”229px” height=”709px” max_height=”854px” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/affiliate.wcu.edu\/boonelab\/wp-content\/uploads\/sites\/408\/2025\/10\/0A98A883-20BF-4D2E-8155-4BB6F069A240_1_102_o-scaled-e1761534674855.jpeg” title_text=”0A98A883-20BF-4D2E-8155-4BB6F069A240_1_102_o” show_bottom_space=”off” align=”center” _builder_version=”4.27.4″ _module_preset=”default” width=”100%” min_height=”287.5px” height=”691px” max_height=”995px” custom_margin=”-16px||-57px||false|false” custom_padding=”||6px||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ custom_padding=”0px|0px|43px|0px” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Welcome to the Boone lab!” _builder_version=”4.27.4″ _module_preset=”default” title_font=”|700|||||||” title_text_align=”center” title_text_color=”#592C88″ title_font_size=”35px” min_height=”46.2px” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/affiliate.wcu.edu\/boonelab\/wp-content\/uploads\/sites\/408\/2025\/10\/Home-page-image-1.png” title_text=”Home page image 1″ _builder_version=”4.27.4″ _module_preset=”default” filter_saturate=”103%” filter_brightness=”83%” filter_contrast=”104%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n
Chromatin describes the chaotic and complex interactions of proteins, RNA, and DNA to regulate gene expression, store or compartmentalize DNA, and bridge environmental signals to cellular responses through epigenetic modifications to chromatin itself.<\/p>\n
Protein dynamics and concentration are critical to many chromatin and epigenetic mechanisms to regulate gene expression. Accumulation of epigenetic enzymes, readers\/writer complexes, and transcriptional machinery occurs to silence or activate genes. However, many questions remain. How are these processes specific and dynamic, while in the heavily cramped nuclear space? How do these mechanisms maintain proteostasis while efficiently and specifically localizing large amounts of proteins to regulate gene expression? Can these epigenetic mechanisms be co-opted for synthetic biology purposes and applications?<\/p>\n
Our lab is focused on answering these questions by understanding how plants use protein accumulation and regulation to control gene expression. Our long-term goal is to create plant-specific protein tools to form protein-specific gene regulatory compartments using plant-specific processes.<\/p>\n
Please reach out to us with any questions,\u00a0 collaborations, or interest in joining the lab.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Chromatin describes the chaotic and complex interactions of proteins, RNA, and DNA to regulate gene expression, store or compartmentalize DNA, and bridge environmental signals to cellular responses through epigenetic modifications to chromatin itself. Protein dynamics and concentration are critical to many chromatin and epigenetic mechanisms to regulate gene expression. Accumulation of epigenetic enzymes, readers\/writer complexes, […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-6","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/pages\/6","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":25,"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"predecessor-version":[{"id":470,"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/pages\/6\/revisions\/470"}],"wp:attachment":[{"href":"https:\/\/affiliate.wcu.edu\/boonelab\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}